This program is subject to change
Ömer Yilmaz (MIT Koch Institute for Integrative Cancer Research, Cambridge, MA, USA)
Chairs: Erica Pranzini (University of Florence, Italy) – Albert Thommen (The Francis Crick Institute, UK)
Chairs: Erica Pranzini (University of Florence, Italy) – Albert Thommen (The Francis Crick Institute, UK)
Elisabeth Letellier (Univ. of Luxembourg, Luxembourg)
Leveraging the gut microbiome for CRC prevention and therapy: Insights from microbial metabolism and dietary interventions
Chairs: Ophélie Renoult (UCLouvain, Belgium) – Mattia Marinucci (UMC Utrecht, The Netherlands)
16:15 – 16:45 Carolin Ector (Charité Comprehensive Cancer Center, Berlin, Germany)
The circadian clock landscape in breast cancer cell models and its role in shaping treatment responses
16:45 – 17:45 Short talks (12 min + 3 min Q&A)
Short talk #1: Philippine Bruno (UCLouvain, IREC)
Circadian regulations of lipid metabolism in cancer: toward optimized use of metabolism-targeting therapies
Short talk #2: Konstantinos Kolliopoulos (VIB – KU Leuven)
Methionine restriction inhibits breast cancer metastasis
Short talk #3: Roberta Noè (University of Padua – Veneto Institute of Molecular Medicine)
Do sweetened beverages increase pancreatic cancer risk? Interrogating the role of fructose-to-acetate conversion
Short talk #4: Axell-Natalie Kouakou (UCLouvain, LDRI)
Impact of diet-induced obesity on tumor growth and response to therapy in a preclinical melanoma model
Chairs: Donatella Delle Cave (Italian National Research Council, Italy) – Marco Fantuz (University of Padua, Italy)
9:00 – 9:45 Sara Zanivan (Univ. of Texas M.D. Anderson Cancer Center, Houston, USA)
Fueling immunity in the TME: metabolism in action
9:45 – 10:30 Short talks (12 min + 3 min Q&A)
Short talk #1: Janice Safi (Institut de Génomique Fonctionnelle)
Mitochondrial transfer confers chemoresistance to glioblastoma stem cells through metabolic rewiring
Short talk #2: Elien Heylen (Barts Cancer Institute, Queen Mary University of London)
Determining the role of pericyte β3-integrin in metabolic reprogramming and the control of breast cancer progression
Short talk #3: Vanessa Vermeirssen (Ghent University)
Modeling glioblastoma metabolism at bulk and single-cell level
Chairs: Victoria Mohring (University of Liège, Belgium) – Diogo Estêvᾶo (University of Porto, Portugal)
11:00 – 11:30 Stéphanie Hugues (Univ. Geneva, Switzerland)
Lymphatic endothelial cells as immunomodulators in cancer
11:30 – 12:15 Short talks (12 min + 3 min Q&A)
Short talk #1: Stefania Oliveto (INGM, Policlinico Milano, PAD INVERNIZZI)
Translational control drives Treg cell fate in the tumor microenvironment
Short talk #2: Patricia Nunes (Francis Crick Institute)
Glycerol: an overlooked metabolite in cancer
Short talk #3: Naama Darzi (Weizmann Institute of Science)
Cancer-associated cachexia (CAC) rewires cholesterol metabolism to support tumorigenesis
Chairs: Camilla Elbaek (Centre for Genomic Regulation, Spain) – Jorrit De Waele (University of Antwerp, Belgium)
14:30 – 15:00 Massimiliano Mazzone (VIB Center for Cancer Biology, KU Leuven, Belgium)
Harnessing tumor metabolism to overcome immunosuppression
15:00 – 15:45 Short talks (12 min + 3 min Q&A)
Short talk #1: Irene Fiorilla (Department of Science and Technological Innovation, University of Eastern Piedmont)
Bi-directional crosstalk between NAD/NAMPT and IFN-Γ/PD-L1 axes in melanoma
Short talk #2: Lobna Oueslati (ULiège – GIGA institute)
Wobble tRNA modification shapes tumor associated neutrophils in metastatic breast cancer
Short talk #3: Erina Vlashi (University of California Los Angeles)
Serine metabolism regulates antitumor immune response during radiation therapy in glioma
Chairs: Maria Virginia Giolito (UCLouvain, Belgium) – Carlotta Paoli (University of Padua, Italy)
16:15 – 16:45 Pedro Friedmann Angeli (University of Würzburg, Germany)
Molecular mechanisms regulating the formation, prevention, and repair of (per)oxidized phospholipids
16:45 – 17:30 Short talks (12 min + 3 min Q&A)
Short talk #1: Julie Vignau (UCLouvain, IREC)
Lipid metabolism reprogramming supports escape to anti-EGFR therapy in head and neck cancers
Short talk #2: Cloé Tessier (U1312 Bordeaux Institute of Oncology)
Role of lipid droplet catabolism in glioblastoma
Short talk #3: Nor Eddine Sounni (ULiège – GIGA institute)
Exploring the role of lipid metabolism in ferroptosis and therapeutic resistance in cancer
Chair: Akeila Bellahcène (University of Liège, Belgium)
Dr Giovanni Monaco (Cell Rep Med), Dr Maria Garcia Fernandez (Nat Commun) & Deniz Senyilmaz (EMBO Rep)
Chairs: Claire Larrieu (University of Bordeaux, France) – Laurane Beckers (UCLouvain, Belgium)
9:00 – 9:45 Theodore Alexandrov (UC San Diego, CA, USA)
Spatial single-cell metabolomics: decoding metabolism one cell at a time
9:45 – 10:30 Short talks (12 min + 3 min Q&A)
Short talk #1: Luca Rappez (EMBL Barcelona)
Inferring super-resolved spatial metabolomics from microscopy
Short talk #2: Gilles Rademaker (ULiège – GIGA institute)
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
Short talk #3: Luigi Ippolito (Department of Experimental Biomedical and Clinical Sciences, University of Florence)
Pantothenic acid supports prostate cancer organotropism via heme pathway
Chairs: Arnaud Blomme (University of Liège, Belgium) – Manon Desgres (UCLouvain, Belgium)
11:00 – 11:30 Payam Gammage (CRUK Scotland Institute)
Mitochondrial DNA mutations in cancer metabolism: prevalent and relevant
11:30 – 12:15 Short talks (12 min + 3 min Q&A)
Short talk #1: Anna Benito I Ferrer (Centre de Regulació Genòmica)
Exploiting metabolic vulnerabilities of lung tumors with concomitant mutations in KRAS and TP53
Short talk #2: Miriam Lisci (University of Lausanne)
FBXW7 alleviates c-MYC repression of pyruvate carboxylase to support metabolic flexibility
Short talk #3: Shiran Rabinovich (The Francis Crick Institute)
Loss of Tigar in lung tumours promotes metastasis by boosting cholesterol uptake
Chairs: Engy Vigneron (UCLouvain, Belgium) – Elisa Pirotta (University of Turin, Italy)
14:00 – 14:30 Ferdia Gallagher (CRUK Cambridge Research Institute, UK)
Imaging of tumour metabolism and metabolic heterogeneity in patients
14:30 – 15:30 Short talks (12 min + 3 min Q&A)
Short talk #1: Barbara Mathieu (UCLouvain, LDRI)
A magnetic resonance-guided study to target mitochondrial metabolism and enhance radiosensitivity
Short talk #2: Sébastien Ibanez (UCLouvain, IREC)
Fatty acids are acids: a metabolic convergence under tumor acidosis
Short talk #3: Mehdi Damaghi (Stony Brook University)
Acidic tumor microenvironment drives cancer evolution through sphingolipid-mediated cell state plasticity
Short talk #4: PostdoCaRe Europe network (Maria Virginia Giolito, UCLouvain, Belgium)
Chair: Olivier Feron (UCLouvain, Belgium)
Stine Pedersen (University of Copenhagen, Denmark)
Tumor microenvironment acidosis as driver of cancer stemness and treatment resistance